About Gorlin Syndrome

About the Syndrome

Gorlin Syndrome is a medical condition affecting many body systems and is caused by a fault in just one of the thousands of genes which humans possess. 

Read more: About the Syndrome

Main Features

The condition is characterised by the development of multiple jaw cysts (keratocysts) and/or basal cell carcinomas (BCCs).

Other Features

There are many features which may occur in Gorlin Syndrome, although most are rare.   Some of the features are listed below.

Read more: Other Features

Skeletal

The Gorlin Syndrome gene also has an effect on the development of the skeletal system. This does not progress throughout life and usually causes no ill effects as all.

Read more: Skeletal

Jaw Cysts

The jaw cysts are known as keratocysts because they are filled with keratin, which is the material making up the outer layer of skin, hair and nails. 

Read more: Jaw Cysts

Skin

The following skin problems present in Gorlin Syndrome.

Read more: Skin

Basal Cell Carcinomas

Basal Cell Carcinomas (BCC) can arise in any area of the skin, affecting the face, neck and upper trunk more often than the abdomen, lower trunk and extremities.

Read more: Basal Cell Carcinomas


 Originally produced by Professor P. A. Farndon, Clinical Geneticist, Jim Costello (deceased) and Margaret Costello.  We are reliant on a team of medical advisors for the clinical content of the website. We are grateful for their continuing support. 
Gorlin Syndrome Group is Registered Charity in the UK - No 1096361 
 
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